CNS Langerhans cell histiocytosis: Common hematopoietic origin for LCH-associated neurodegeneration and mass lesions

Author:

McClain Kenneth L.1,Picarsic Jennifer2,Chakraborty Rikhia1,Zinn Daniel1,Lin Howard1,Abhyankar Harshal1,Scull Brooks1,Shih Albert1,Lim Karen Phaik Har13,Eckstein Olive1,Lubega Joseph1,Peters Tricia L.14,Olea Walter1,Burke Thomas1,Ahmed Nabil1,Hicks M. John14,Tran Brandon5,Jones Jeremy5,Dauser Robert6,Jeng Michael7,Baiocchi Robert8,Schiff Deborah9,Goldman Stanton10,Heym Kenneth M.11,Wilson Harry12,Carcamo Benjamin13,Kumar Ashish14,Rodriguez-Galindo Carlos15,Whipple Nicholas S.15,Campbell Patrick15,Murdoch Geoffrey16,Kofler Julia16,Heales Simon17,Malone Marian18,Woltjer Randy19,Quinn Joseph F.19,Orchard Paul20,Kruer Michael C.21,Jaffe Ronald22,Manz Markus G.23,Lira Sergio A.24,Parsons D. Williams125,Merad Miriam26,Man Tsz-Kwong1,Allen Carl E.1ORCID

Affiliation:

1. Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine; Houston Texas

2. Department of Pathology; University of Pittsburgh School of Medicine; Pittsburgh Pennsylvania

3. Graduate Program in Translational Biology and Molecular Medicine; Baylor College of Medicine; Houston Texas

4. Department of Pathology; Baylor College of Medicine; Houston Texas

5. Department of Radiology; Baylor College of Medicine; Houston Texas

6. Department of Neurosurgery; Baylor College of Medicine; Houston Texas

7. Department of Pediatrics; Stanford University School of Medicine; Palo Alto California

8. Department of Internal Medicine; The Ohio State University; Columbus Ohio

9. Department of Pediatrics; University of California-San Diego; La Jolla California

10. Medical City Children's Hospital, Dallas Texas and Texas Oncology; Pennsylvania

11. Department of Pediatrics; Cook Children's Medical Center; Fort Worth Texas

12. Department of Pathology; Texas Tech University Health Sciences Center El Paso; El Paso Texas

13. Department of Pediatrics; Texas Tech University Health Sciences Center El Paso; El Paso Texas

14. Cancer and Blood Diseases Institute; Cincinnati Children's Hospital Medical Center; Cincinnati Ohio

15. St. Jude Children's Research Hospital; Memphis Tennessee

16. Department of Pathology, Division of Neuropathology; University of Pittsburgh School of Medicine; Pittsburgh Pennsylvania

17. Chemical Pathology; Great Ormond Street Hospital for Children; London UK

18. Laboratory Medicine; Great Ormond Street Hospital for Children; London UK

19. Layton Aging and Alzheimer's Disease Center; Oregon Health and Science University; Portland Oregon

20. Department of Pediatrics; University of Minnesota; Minneapolis Minnesota

21. Barrow Neurological Institute, Phoenix Children's Hospital; Child Health, Neurology & Genetics; University of Arizona College of Medicine; Phoenix Arizona

22. Department of Pathology, Magee-Women's Hospital of UPMC; University of Pittsburgh School of Medicine; Pittsburgh Pennsylvania

23. Division of Hematology, University of Zurich; University Hospital Zurich; Zurich Switzerland

24. Immunology Institute; Icahn School of Medicine; New York New York

25. Department of Molecular and Human Genetics; Baylor College of Medicine; Houston Texas

26. Department of Oncological Sciences, Tisch Cancer Institute; Icahn School of Medicine; New York New York

Funder

HistioCure Foundation

National Institutes of Health

NIH SPORE in Lymphoma

Alex's Lemonade Stand Foundation for Childhood Cancer

American Society of Hematology Scholar Award

Stand Up to Cancer-St. Baldrick's Pediatric Dream Team Translational Research Grant

St. Baldrick's Foundation

North American Consortium for Histiocytosis Research

Publisher

Wiley

Subject

Cancer Research,Oncology

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