Structure of HIV-1 reverse transcriptase/d4TTP complex: Novel DNA cross-linking site and pH-dependent conformational changes-Reference-Cited by-同舟云学术

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Structure of HIV-1 reverse transcriptase/d4TTP complex: Novel DNA cross-linking site and pH-dependent conformational changes

Published:2018-12-22 Issue:3 Volume:28 Page:587-597
ISSN:0961-8368
Container-title:Protein Science
language:en
Short-container-title:Protein Science

Author:

Martinez Sergio E.¹²^ORCID,Bauman Joseph D.¹,Das Kalyan²^ORCID,Arnold Eddy¹

Affiliation:

1. Center for Advanced Biotechnology and Medicine, and Department of Chemistry and Chemical Biology; Rutgers University; Piscataway New Jersey 08854

2. Rega Institute for Medical Research and Department of Microbiology and Immunology; KU Leuven, Leuven 3000 Belgium

Funder

National Institute of Allergy and Infectious Diseases

National Institutes of Health

Publisher

Wiley

Subject

Molecular Biology,Biochemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/pro.3559/fullpdf

Reference36 articles.

1. Targets for inhibition of HIV replication: entry, enzyme action, release and maturation;Sierra-Aragon;Intervirology,2012

2. Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition;Sarafianos;J Mol Biol,2009

3. HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism;Das;Nat Struct Mol Biol,2012

4. Has the phasing out of stavudine in accordance with changes in WHO guidelines led to a decrease in single-drug substitutions in first-line antiretroviral therapy for HIV in Sub-Saharan Africa?;Brennan;AIDS,2017

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1. Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine;Proceedings of the National Academy of Sciences;2022-07-19

2. Cryo-EM structures of Doravirine and Rilpivirine with HIV-1 Reverse Transcriptase/DNA Aptamer – Nonnucleoside Inhibitor Resistance by E138K and M184I Mutations;2022-02-27

3. Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket – targeting P-pocket by fragment screening;Nature Communications;2021-12

4. Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket – Targeting P-pocket by fragment screening;2021-07-04

5. Current Advances in Covalent Stabilization of Macromolecular Complexes for Structural Biology;Bioconjugate Chemistry;2021-04-16

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