Low‐dose total‐body carbon‐ion irradiations induce early transcriptional alteration without late Alzheimer's disease‐like pathogenesis and memory impairment in mice

Author:

Wang Bing1,Tanaka Kaoru1,Ji Bin2,Ono Maiko2,Fang Yaqun3,Ninomiya Yasuharu1,Maruyama Kouichi1,Izumi‐Nakajima Nakako3,Begum Nasrin4,Higuchi Makoto2,Fujimori Akira3,Uehara Yoshihiko5,Nakajima Tetsuo1,Suhara Tetsuya2,Nenoi Mitsuru1

Affiliation:

1. Research Center for Radiation ProtectionNational Institute of Radiological SciencesChiba Japan

2. Molecular Imaging CenterNational Institute of Radiological SciencesChiba Japan

3. Research Center for Charged Particle TherapyNational Institute of Radiological SciencesChiba Japan

4. Center for Nuclear Medicine and UltrasoundRajshahi Medical College Hospital CampusRajshahi People's Republic of Bangladesh

5. Graduate School of MedicineTohoku UniversitySendai Japan

Funder

Budget for Nuclear Research from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan

Aomori Prefectural Government, Japan

Nuclear Researchers Exchange Programme 2011 supported by the MEXT

Nuclear Safety Research Association of Japan

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience

Reference60 articles.

1. Pathogenesis of Irradiation-Induced Cognitive Dysfunction

2. Alzheimer's Disease International. World Alzheimer Report2010: The global economic impact of dementia. Alzheimer's Disease International website. Available from:http://www.alz.co.uk/research/files/WorldAlzheimerReport2010.pdf (last access date 14 August 2013).

3. Biological characteristics of carbon-ion therapy

4. Subacute brain atrophy after radiation therapy for malignant brain tumor

5. Chromatographic separation of reaction products from the choline acetyltransferase and carnitine acetyltransferase assay: differential ChAT and CrAT activity in brain extracts from Alzheimer’s disease versus controls

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