Twenty‐eight days of repeated dose sub‐acute toxicological evaluation of polyherbal Ayurvedic medicine BPGrit in Sprague–Dawley rats

Author:

Balkrishna Acharya1234,Sinha Sandeep1,Bhattacharya Kunal1,Varshney Anurag125

Affiliation:

1. Drug Discovery and Development Division Patanjali Research Foundation Haridwar India

2. Department of Allied and Applied Sciences University of Patanjali, Patanjali Yog Peeth Haridwar India

3. Patanjali Yog Peeth (UK) Trust Glasgow UK

4. Vedic Acharya Samaj Foundation Inc., NFP 21725 CR 33 Groveland Florida USA

5. Special Centre for Systems Medicine Jawaharlal Nehru University New Delhi India

Abstract

AbstractA pre‐clinical toxicological evaluation of herbal medicines is necessary to identify any underlying health‐associated side effects, if any. BPGrit is an Ayurveda‐based medicine prescribed for treating hypertensive conditions. High‐performance liquid chromatography‐based analysis revealed the presence of gallic acid, ellagic acid, coumarin, cinnamic acid, guggulsterone E, and guggulsterone Z in BPGrit. For sub‐acute toxicity analysis of BPGrit, male and female Sprague–Dawley rats were given repeated oral gavage at 100, 300, and 1000 mg/kg body weight/day dosages for 28 days, followed by a 14‐day recovery phase. No incidences of mortality, morbidity, or abnormal clinical signs were observed in BPGrit‐treated rats throughout the study period. Also, the body weight and food consumption habits of the experimental animals did not change during the study duration. Hematological, biochemical, and histopathological analysis did not indicate any abnormal changes occurring in the BPGrit‐treated rats up to the highest tested dose of 1000 mg/kg body weight/day. Finally, the study established the “no‐observed‐adverse‐effect level” for BPGrit at >1000 mg/kg body weight/day in Sprague–Dawley rats.

Publisher

Wiley

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