Efficacy of BRAF-Inhibitor Therapy in BRAF V600E-Mutated Adult Langerhans Cell Histiocytosis-Reference-Cited by-同舟云学术

Efficacy of BRAF-Inhibitor Therapy in BRAF V600E-Mutated Adult Langerhans Cell Histiocytosis

Published:2020-10-12 Issue:12 Volume:25 Page:1001-1004
ISSN:1083-7159
Container-title:The Oncologist
language:en
Short-container-title:

Author:

Hazim Antonious Z.¹,Ruan Gordon J.¹,Ravindran Aishwarya²,Abeykoon Jithma P.³,Scheckel Caleb³,Vassallo Robert⁴,Ryu Jay H.⁴,Tobin W. Oliver⁵,Koster Matthew J.⁶,Bennani N. Nora³,Rech Karen L.²,Young Jason R.⁷,Shah Mithun V.³,Goyal Gaurav⁸⁹,Go Ronald S.³

Affiliation:

1. Division of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA

2. Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA

3. Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA

4. Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA

5. Division of Neurology, Mayo Clinic, Rochester, Minnesota, USA

6. Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA

7. Division of Radiology, Mayo Clinic, Rochester, Minnesota, USA

8. Division of Hematology-Oncology, University of Alabama at Birmingham, Birmingham, Alabama, USA

9. Department of Research Collaborator (limited-tenure), on behalf of the Mayo Clinic Histiocytosis Working Group Mayo Clinic, Rochester, Minnesota, USA

Abstract

Abstract Langerhans cell histiocytosis (LCH) is a rare histiocytic neoplasm. To date, there is a lack of U.S. Food and Drug Administration–approved treatments in adult LCH to establish optimal first-line therapy. We conducted a retrospective, single-center case series evaluating the use of BRAF inhibitors in adult patients with BRAFV600E- LCH proven by biopsy. Our case series is the first to report the use of BRAF inhibitors as first-line therapy in adults with LCH. We also report the efficacy with single-agent dabrafenib in adult LCH. All but one of our patients had favorable response to targeted therapy.

Funder

University of Iowa/Mayo Clinic Lymphoma

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/onco.13541

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