Advanced control strategies for the multicolumn countercurrent solvent gradient purification process

Author:

Papathanasiou Maria M.12,Avraamidou Styliani12,Oberdieck Richard12,Mantalaris Athanasios1,Steinebach Fabian3,Morbidelli Massimo3,Mueller-Spaeth Thomas4,Pistikopoulos Efstratios N.2

Affiliation:

1. Dept. of Chemical Engineering, Centre for Process Systems Engineering (CPSE); Imperial College London; SW7 2AZ Lodnon U.K

2. Artie McFerrin Dept. of Chemical Engineering; Texas A&M University; College Station TX 77843

3. Institute for Chemical and Bioengineering; ETH Zurich; Wolfgang-Pauli-Str. 10/HCI F 129 CH-8093 Zurich Switzerland

4. Dept. of Chemistry and Applied Biosciences, ChromaCon AG; Technoparkstr. 1 CH-8005 Zurich Switzerland

Publisher

Wiley

Subject

General Chemical Engineering,Environmental Engineering,Biotechnology

Reference49 articles.

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2. Process economics of industrial monoclonal antibody manufacture;Farid;J ChromatogrB.,2007

3. Research TM. 2015 http://www.transparencymarketresearch.com/monoclonal-antibodies.html

4. A new, integrated, continuous purification process template for monoclonal antibodies: process modeling and cost of goods studies;Xenopoulos;J Biotechnol.,2015

5. Trends in upstream and downstream process development for antibody manufacturing;Gronemeyer;Bioengineering.,2014

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