Staging Parkinson's disease according to the MNCD classification correlates with caregiver burden

Author:

Santos‐García Diego1,de Deus Fonticoba Teresa2,Cores Bartolomé Carlos1,Feal Painceiras María J.1,García Díaz Iago1,Alvarado María Cristina Íñiguez1,Paz Jose Manuel1,Jesús Silvia34,Cosgaya Marina5,Caldentey Juan García6,Caballol Nuria7,Legarda Ines8,Hernández Vara Jorge49,Cabo Iria10,López Manzanares Lydia11,González Aramburu Isabel412,Ávila Rivera Maria A.13,Gómez Mayordomo Víctor14,Nogueira Víctor15,Dotor García‐Soto Julio16,Borrué Carmen17,Solano Vila Berta18,Álvarez Sauco María19,Vela Lydia20,Escalante Sonia21,Cubo Esther22,Mendoza Zebenzui23,Martínez Castrillo Juan C.24,Sánchez Alonso Pilar25,Alonso Losada Maria G.26,López Ariztegui Nuria27,Gastón Itziar28,Kulisevsky Jaime429,Seijo Manuel10,Valero Caridad30,Alonso Redondo Ruben15,Buongiorno Maria Teresa31,Ordás Carlos32,Menéndez‐González Manuel33,McAfee Darrian34,Martinez‐Martin Pablo4,Mir Pablo34,

Affiliation:

1. Department of Neurology, CHUAC Complejo Hospitalario Universitario de A Coruña A Coruña Spain

2. Department of Neurology, CHUF Complejo Hospitalario Universitario de Ferrol A Coruña Spain

3. Department of Neurology, Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla Seville Spain

4. CIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas) Madrid Spain

5. Department of Neurology Hospital Clínic de Barcelona Barcelona Spain

6. Department of Neurology Centro Neurológico Oms 42 Palma de Mallorca Spain

7. Department of Neurology, Consorci Sanitari Integral Hospital Moisés Broggi Sant Joan Despí Barcelona Spain

8. Department of Neurology Hospital Universitario Son Espases Palma de Mallorca Spain

9. Department of Neurology Hospital Universitario Vall d´Hebron Barcelona Spain

10. Department of Neurology Complejo Hospitalario Universitario de Pontevedra (CHOP) Pontevedra Spain

11. Department of Neurology Hospital Universitario La Princesa Madrid Spain

12. Department of Neurology Hospital Universitario Marqués de Valdecilla – IDIVAL Santander Spain

13. Department of Neurology, Consorci Sanitari Integral Hospital General de L´Hospitalet, L´Hospitalet de Llobregat Barcelona Spain

14. Department of Neurology, Institute of Neuroscience Vithas Madrid La Milagrosa University Hospital, Vithas Hospital Group Madrid Spain

15. Department of Neurology Hospital Universitario Lucus Augusti Lugo Spain

16. Department of Neurology Hospital Universitario Virgen Macarena Sevilla Spain

17. Department of Neurology Hospital Infanta Sofía Madrid Spain

18. Department of Neurology Institut d'Assistència Sanitària (IAS) – Institut Català de la Salut Girona Spain

19. Department of Neurology Hospital General Universitario de Elche Elche Spain

20. Department of Neurology Fundación Hospital de Alcorcón Madrid Spain

21. Department of Neurology Hospital de Tortosa Verge de la Cinta (HTVC) Tortosa Tarragona Spain

22. Department of Neurology Complejo Asistencial Universitario de Burgos Burgos Spain

23. Department of Neurology Hospital Universitario de Canarias San Cristóbal de la Laguna Santa Cruz de Tenerife Spain

24. Department of Neurology Hospital Universitario Ramón y Cajal, IRYCIS Madrid Spain

25. Department of Neurology Hospital Universitario Puerta de Hierro Madrid Spain

26. Department of Neurology Hospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Vigo (CHUVI) Vigo Spain

27. Department of Neurology Complejo Hospitalario de Toledo Toledo Spain

28. Department of Neurology Complejo Hospitalario de Navarra Pamplona Spain

29. Department of Neurology Hospital de Sant Pau Barcelona Spain

30. Department of Neurology Hospital Arnau de Vilanova Valencia Spain

31. Department of Neurology Hospital Universitari Mutua de Terrassa Terrassa Barcelona Spain

32. Department of Neurology Hospital Rey Juan Carlos Madrid Spain

33. Department of Neurology Hospital Universitario Central de Asturias Oviedo Spain

34. University of Maryland School of Medicine Baltimore Maryland USA

Abstract

AbstractBackground and objectiveRecently, we demonstrated that staging Parkinson's disease (PD) with a novel simple classification called MNCD, based on four axes (motor, non‐motor, cognition, and dependency) and five stages, correlated with disease severity and patients’ quality of life. Here, we analyzed the correlation of MNCD staging with PD caregiver's status.Patients and methodsData from the baseline visit of PD patients and their principal caregiver recruited from 35 centers in Spain from the COPPADIS cohort from January 2016 to November 2017 were used to apply the MNCD total score (from 0 to 12) and MNCD stages (from 1 to 5) in this cross‐sectional analysis. Caregivers completed the Zarit Caregiver Burden Inventory (ZCBI), Caregiver Strain Index (CSI), Beck Depression Inventory‐II (BDI‐II), PQ‐10, and EUROHIS‐QOL 8‐item index (EUROHIS‐QOL8).ResultsTwo hundred and twenty‐four PD patients (63 ± 9.6 years old; 61.2% males) and their caregivers (58.5 ± 12.1 years old; 67.9% females) were included. The frequency of MNCD stages was 1, 7.6%; 2, 58.9%; 3, 31.3%; and 4–5, 2.2%. A more advanced MNCD stage was associated with a higher score on the ZCBI (p < .0001) and CSI (p < .0001), and a lower score on the PQ‐10 (p = .001), but no significant differences were observed in the BDI‐II (p = .310) and EUROHIS‐QOL8 (p = .133). Moderate correlations were observed between the MNCD total score and the ZCBI (r = .496; p < .0001), CSI (r = .433; p < .0001), and BDI‐II (r = .306; p < .0001) in caregivers.ConclusionStaging PD according to the MNCD classification is correlated with caregivers’ strain and burden.

Publisher

Wiley

Subject

Behavioral Neuroscience

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