Tocilizumab is safe and tolerable and reduces C ‐reactive protein concentrations in the plasma and cerebrospinal fluid of ALS patients

Author:

Milligan Carol1,Atassi Nazem2,Babu Suma2,Barohn Richard J.3,Caress James B.4,Cudkowicz Merit E.2,Evora Armineuza2,Hawkins Gregory A.5,Wosiski‐Kuhn Marlena1,Macklin Eric A.6,Shefner Jeremy M.7,Simmons Zachary8ORCID,Bowser Robert P.9,Ladha Shafeeq S.7

Affiliation:

1. Department of Neurobiology and Anatomy Wake Forest University Winston‐Salem North Carolina USA

2. Department of Neurology Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital Boston Massachusetts USA

3. Department of Neurology Kansas University Kansas City Kansas USA

4. Department of Neurology Wake Forest University Winston‐Salem North Carolina USA

5. Department of Biochemistry and Center for Precision Medicine Wake Forest University Winston‐Salem North Carolina USA

6. Department of Medicine, Biostatistics Center Harvard Medical School, Massachusetts General Hospital Boston Massachusetts USA

7. Department of Neurology Gregory W. Fulton ALS and Neuromuscular Disease Center Barrow Neurological Institute, St. Josephʼs Hospital and Medical Center Phoenix Arizona USA

8. Department of Neurology Penn State Health Milton S. Hershey Medical Center Hershey Pennsylvania USA

9. Departments of Neurology and Neurobiology Gregory W. Fulton ALS and Neuromuscular Disease Center Barrow Neurological Institute, St. Josephʼs Hospital and Medical Center Phoenix Arizona USA

Funder

National Center for Advancing Translational Sciences

Publisher

Wiley

Subject

Physiology (medical),Cellular and Molecular Neuroscience,Neurology (clinical),Physiology

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