A High-Throughput (HTS) Assay for Enzyme Reaction Phenotyping in Human Recombinant P450 Enzymes Using LC-MS/MS

Author:

Li Xiaofeng1,Suhar Tom1,Glass Lateca1,Rajaraman Ganesh1

Affiliation:

1. AbbVie, Drug Metabolism; North Chicago Illinois

Publisher

John Wiley & Sons, Inc.

Reference33 articles.

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2. Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin;Bertilsson;Clin. Pharmacol. Therapeut.,1992

3. Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions;Bertz;Clin. Pharmacokinet.,1997

4. Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA-expressed human cytochromes P-450;Busby;Drug Metab. Disposition,1999

5. Coprescription of terfenadine and erythromycin or ketaconazole: An assessment of potential harm;Carlson;J. Am. Pharm. Assoc.,1996

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