No evidence of association between either Modic change or disc degeneration and five circulating inflammatory proteins

Author:

Compte Roger1ORCID,Freidin Maxim B.2ORCID,Granville Smith Isabelle1ORCID,Le Maitre Christine L.3ORCID,Vaitkute Dovile1,Nessa Ayrun1,Lachance Genevieve1,Williams Frances M. K.1ORCID

Affiliation:

1. Department of Twin Research and Genetic Epidemiology King's College London London UK

2. Department of Biology, School of Biological and Behavioural Sciences Queen Mary University of London London UK

3. Division of Clinical Medicine, School of Medicine and Population Health University of Sheffield Sheffield UK

Abstract

AbstractIntroductionIntervertebral disc degeneration and Modic change are the main spinal structural changes associated with chronic low back pain (LBP). Both conditions are thought to manifest local inflammation and if inflammatory proteins translocate to the blood circulation could be detected systemically. The work here assesses whether the presence of disc degeneration is associated with detectable blood level changes of five inflammatory markers and whether chronic LBP is associated with these changes.Materials and MethodsTwo hundred and forty TwinsUK cohort participants with both MRI disc degeneration grade and Modic change extent, and IL‐6, IL‐8, IL‐8 TNF, and CX3CL1 protein blood concentration measurements were included in this work. Linear mixed effects models were used to test the association of blood cytokine concentration with disc degeneration score and Modic change volumetric score. Association of chronic LBP status from questionnaires with disc degeneration, Modic change, and cytokine blood concentration was also tested.ResultsNo statistically significant association between disc degeneration or Modic change with cytokine blood concentration was found. Instead, regression analysis pointed strong association between cytokine blood concentration with body mass index for IL‐6 and with age for IL‐6 and TNF. Mild association was found between IL‐8 blood concentration and body mass index. Additionally, LBP status was associated with Modic change volumetric score but not associated with any cytokine concentration.ConclusionsWe found no evidence that Modic change and disc degeneration are able to produce changes in tested blood cytokine concentration. However, age and body mass index have strong influence on cytokine concentration and both are associated with the conditions studied which may confound associations found in the literature. It is then unlikely that cytokines produced in the disc or vertebral bone marrow induce chronic LBP.

Funder

Horizon 2020 Framework Programme

Publisher

Wiley

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