Synergistic associations of <i>CD33</i> variants and hypertension with brain and cognitive aging among dementia‐free older adults: A population‐based study-Reference-Cited by-同舟云学术

Synergistic associations of CD33 variants and hypertension with brain and cognitive aging among dementia‐free older adults: A population‐based study

Published:2024-08-30 Issue: Volume: Page:
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Zhu Min¹²³,Tian Xunyao²³,Han Xiaodong⁴,Ma Yixun¹³,Fa Wenxin¹³,Wang Nan²³,Liu Rui¹²³,Dong Yi¹²³,Ren Yifei²³,Liu Cuicui¹²³,Tian Na¹²³,Zhang Heng¹²³,Song Lin¹²³,Tang Shi¹²³,Cong Lin¹²³,Wang Yongxiang¹²³⁵⁶,Hou Tingting¹²³,Qiu Chengxuan¹⁵⁶,Du Yifeng¹²³⁵^ORCID,

Affiliation:

1. Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong P.R. China

2. Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Neurology, Shandong Provincial Hospital Shandong University Jinan Shandong P.R. China

3. Shandong Provincial Clinical Research Center for Neurological Diseases Jinan Shandong P.R. China

4. Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases Capital Medical University Beijing P.R. China

5. Institute of Brain Science and Brain‐Inspired Research Shandong First Medical University & Shandong Academy of Medical Sciences Jinan Shandong P.R. China

6. Aging Research Center and Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society Karolinska Institute‐Stockholm University Stockholm Sweden

Abstract

AbstractINTRODUCTIONCD33 rs3865444 and hypertension (HTN) are related to cognitive impairment, individually. However, little is known about their combined effects on cognitive function in older adults.METHODSThis population‐based study included 4368 dementia‐free participants (age ≥65 years) in the Multimodal Interventions to Delay Dementia and Disability in Rural China (MIND‐China), with data available in 1044 persons for gray matter volume and 85 persons for cerebral blood flow (CBF). We used general linear regression and mediation models to examine the associations of rs3865444 and HTN with cognition, brain atrophy, and CBF.RESULTSAmong rs3865444 CC carriers, HTN and late‐life HTN were significantly associated with impaired cognition. Midlife and late‐life HTN were correlated with brain atrophy. CD33 rs3865444 CC moderated the mediation effect of gray matter volume on the association between HTN and global cognition. HTN was correlated with low CBF in rs3865444 CC carriers.DISCUSSIONThere are synergistic associations of CD33 rs3865444 and HTN with brain and cognitive aging in dementia‐free older adults.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Postdoctoral Innovation Project of Shandong Province

Vetenskapsrådet

Forskningsrådet om Hälsa, Arbetsliv och Välfärd

Swedish Foundation for International Cooperation in Research and Higher Education

Publisher

Wiley

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