Electroacupuncture modulates abnormal brain connectivity after ischemia reperfusion injury in rats: A graph theory‐based approach

Author:

Li Si‐Si12,Xing Xiang‐Xin3,Hua Xu‐Yun4,Zhang Yu‐Wen5,Wu Jia‐Jia3,Shan Chun‐Lei136,Wang He5,Zheng Mou‐Xiong4,Xu Jian‐Guang16ORCID

Affiliation:

1. School of Rehabilitation Science Shanghai University of Traditional Chinese Medicine Shanghai China

2. Department of Physical Medicine and Rehabilitation The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China

3. Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Shanghai China

4. Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Shanghai China

5. Institute of Science and Technology for Brain‐Inspired Intelligence Fudan University Shanghai China

6. Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of Education Shanghai China

Abstract

AbstractBackgroundElectroacupuncture (EA) has been shown to facilitate brain plasticity‐related functional recovery following ischemic stroke. The functional magnetic resonance imaging technique can be used to determine the range and mode of brain activation. After stroke, EA has been shown to alter brain connectivity, whereas EA's effect on brain network topology properties remains unclear. An evaluation of EA's effects on global and nodal topological properties in rats with ischemia reperfusion was conducted in this study.Methods and resultsThere were three groups of adult male Sprague‐Dawley rats: sham‐operated group (sham group), middle cerebral artery occlusion/reperfusion (MCAO/R) group, and MCAO/R plus EA (MCAO/R + EA) group. The differences in global and nodal topological properties, including shortest path length, global efficiency, local efficiency, small‐worldness index, betweenness centrality (BC), and degree centrality (DC) were estimated. Graphical network analyses revealed that, as compared with the sham group, the MCAO/R group demonstrated a decrease in BC value in the right ventral hippocampus and increased BC in the right substantia nigra, accompanied by increased DC in the left nucleus accumbens shell (AcbSh). The BC was increased in the right hippocampus ventral and decreased in the right substantia nigra after EA intervention, and MCAO/R + EA resulted in a decreased DC in left AcbSh compared to MCAO/R.ConclusionThe results of this study provide a potential basis for EA to promote cognitive and motor function recovery after ischemic stroke.

Funder

Shanghai Rising-Star Program

National Natural Science Foundation of China

Publisher

Wiley

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