Managing Potential Drug Interactions of Nirmatrelvir/Ritonavir in COVID‐19 Patients: A Perspective from an Israeli Cross‐Sector Collaboration

Author:

Guy‐Alfandary Shiri1,Zhurat Sasha2,Berlin Maya2,De Haan Tal2,Gueta Itai3,Shihmanter Renata4,Golik Ahuva5,Berkovitch Matitiahu2,Eyal Sara6,Goldstein Lee H.7

Affiliation:

1. Health Division Pharmacy and Pharmacology Department Maccabi Healthcare Services Tel‐Aviv Israel

2. Clinical Pharmacology and Toxicology Unit Shamir Medical Center (Assaf Harofeh) Affiliated to Sackler Faculty of Medicine Tel‐Aviv University Tel Aviv Israel

3. The Institute of Clinical Pharmacology and Toxicology Internal Medicine A, Sheba Medical Center, Tel Hashomer, Israel, Affiliated to Sackler Faculty of Medicine, Tel‐Aviv University Tel Aviv Israel

4. Clinical Pharmacology Unit Kaplan Medical Center, Rehovot, Israel, Affiliated to The Hebrew University of Jerusalem Jerusalem Israel

5. Adelson School of Medicine Ariel University Ariel Israel

6. Institute for Drug Research School of Pharmacy The Hebrew University of Jerusalem Jerusalem Israel

7. Clinical Pharmacology Unit Haemek Medical Center, Afula, Israel, Affiliated to The Bruce Rapapport School of Medicine Technion Israel

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference10 articles.

1. FDA.Fact sheet for healthcare providers: emergency use authorization for paxlovid. Revised December 22 2021. Accessed February 18 2021.

2. Using nirmatrelvir/ritonavir in patients with epilepsy: An update from the Israeli chapter of the International League Against Epilepsy

3. Ritonavir is the best alternative to ketoconazole as an index inhibitor of cytochrome P450-3A in drug-drug interaction studies

4. Dose–Response of Ritonavir on Hepatic CYP3A Activity and Elvitegravir Oral Exposure

5. FDA.Drug development and drug interactions: table of substrates inhibitors and inducers (2020). March 10 2020. Accessed January 21 2022.

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