First phase 1 clinical study of olaparib in pediatric patients with refractory solid tumors

Author:

Takagi Masatoshi1ORCID,Ogawa Chitose2,Iehara Tomoko3,Aoki‐Nogami Yuki2,Ishibashi Eri4,Imai Minoru4,Kimura Toshimi5,Nagata Masashi6ORCID,Yasuhara Masato6,Masutani Mitsuko7,Yoshimura Kenichi89,Tomizawa Daisuke10,Ogawa Atsushi11,Yonemori Kan12,Morishita Aoi1,Miyamoto Satoshi1,Takita Junko13,Kihara Tetsuro4,Nobori Kiyoshi14,Hasebe Kazuhisa4,Miya Fuyuki15,Ikeda Sadakatsu16,Shioda Yoko10,Matsumoto Kimikazu10,Fujimura Junya17,Mizutani Shuki1,Morio Tomohiro1,Hosoi Hajime3,Koike Ryuji14

Affiliation:

1. Department of Pediatrics and Developmental Biology Tokyo Medical and Dental University, Bunkyo‐ku Tokyo Japan

2. Department of Pediatric Oncology National Cancer Center Hospital, Chuo‐ku Tokyo Japan

3. Department of Pediatrics Kyoto Prefectural University of Medicine, Kamigyo‐ku Kyoto Japan

4. University Research Administration Division, Tokyo Medical and Dental University, Bunkyo‐ku Tokyo Japan

5. Department of Pharmacy Tokyo Women's Medical University, Shinjuku‐ku Tokyo Japan

6. Department of Pharmacokinetics and Pharmacodynamics Tokyo Medical and Dental University, Bunkyo‐ku Tokyo

7. Department of Molecular and Genomic Biomedicine, Center for Bioinformatics and Molecular Medicine Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan

8. Innovative Clinical Research Center Kanazawa University Kanazawa Ishikawa Japan

9. Future Medical Center Hiroshima University Hospital, Minami‐ku Hiroshima Japan

10. National Center for Child Health and Development Children's Cancer Center, Setagaya‐ku Tokyo Japan

11. Pediatrics, Niigata Cancer Center Hospital, Chuo‐ku Niigata Japan

12. Medical Oncology National Cancer Center Hospital, Chuo‐ku Tokyo Japan

13. Department of Pediatrics Kyoto University, Sakyo‐ku Kyoto Japan

14. Medical Innovation Promotion Center Tokyo Medical and Dental University, Bunkyo‐ku Tokyo Japan

15. Department of Medical Science Mathematics Medical Research Institute, Tokyo Medical and Dental University, Bunkyo‐ku Tokyo Japan

16. Department of Precision Cancer Medicine, Center for Innovative Cancer Treatment Tokyo Medical and Dental University, Bunkyo‐ku Tokyo Japan

17. Department of Pediatrics and Adolescent Medicine Juntendo University, School of Medicine, Bunkyo‐ku Tokyo Japan

Funder

Japan Agency for Medical Research and Development

Publisher

Wiley

Subject

Cancer Research,Oncology

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