Simulation of phase I metabolism reactions of clozapine by HLM and photocatalytic methods with the use of UHPLC-ESI-MS/MS

Author:

Gawlik Maciej1,Skibiński Robert1ORCID

Affiliation:

1. Department of Medicinal Chemistry; Medical University of Lublin; Lublin Poland

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference20 articles.

1. Biotransformation of clozapine in humans;Dain;Drug Metabolism and Disposition,1997

2. Characterization of human cytochrome P450s involved in the bioactivation of clozapine;Dragovic;Drug Metabolism and Disposition,2013

3. Degradation of amoxicillin, ampicillin and cloxacillin antibiotics in aqueous solution by the UV/ZnO photocatalytic process;Elmolla;Journal of Hazardous Materials,2010

4. Glucuronidation of the second-generation antipsychotic clozapine and its active metabolite N-desmethylclozapine. Potential importance of the UGT1A1 A (TA)7TAA and UGT1A4 L48V polymorphisms;Erickson-Ridout;Pharmacogenetics and Genomics,2012

5. Possible role of free radical formation in clozapine (Clozaril)-induced agranulocytosis;Fischer;Molecular Pharmacology,1991

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