Redesign of LAOBP to bind novel l -amino acid ligands

Author:

Banda-Vázquez Jesús1,Shanmugaratnam Sooruban23,Rodríguez-Sotres Rogelio1,Torres-Larios Alfredo1,Höcker Birte23,Sosa-Peinado Alejandro1

Affiliation:

1. Use National Autonomous University of Mexico, Mexico

2. Max Planck Institute for Developmental Biology; Tübingen Germany

3. Universität Bayreuth; Bayreuth Germany

Funder

UNAM

Consejo Nacional de Ciencia y Tecnología

DFG

Fundación Marcos Moshinsky

Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica, UNAM (PAPIIT-DGAPA)

Publisher

Wiley

Subject

Molecular Biology,Biochemistry

Reference37 articles.

1. Computational design of ligand-binding proteins;Yang;Curr Opin Struct Biol,2017

2. Change in protein-ligand specificity through binding pocket grafting;Scheib;J Struct Biol,2014

3. A conserved mechanism of GABA binding and antagonism is revealed by structure-function analysis of the periplasmic binding protein Atu2422 in Agrobacterium tumefaciens;Planamente;J Bio Chem,2010

4. Structural basis for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein;Oh;J Biol Chem,1994

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