Fasiglifam (TAK‐875) has dual potentiating mechanisms via G α q‐GPR40/FFAR1 signaling branches on glucose‐dependent insulin secretion-Reference-Cited by-同舟云学术

Fasiglifam (TAK‐875) has dual potentiating mechanisms via G α q‐GPR40/FFAR1 signaling branches on glucose‐dependent insulin secretion

Published:2016-04-27 Issue:3 Volume:4 Page:
ISSN:2052-1707
Container-title:Pharmacology Research & Perspectives
language:en
Short-container-title:Pharmacol Res Perspect

Author:

Sakuma Kensuke¹,Yabuki Chiori¹,Maruyama Minoru¹,Abiru Akiko¹,Komatsu Hidetoshi²,Negoro Nobuyuki³,Tsujihata Yoshiyuki¹,Takeuchi Koji¹,Habata Yugo¹,Mori Masaaki¹

Affiliation:

1. Cardiovascular and Metabolic Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan

2. Central Nervous System Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan

3. Inflammation Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan

Funder

Takeda Pharmaceutical Company

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/prp2.237

Reference38 articles.

1. Mitochondrial Ca2+ Uptake 1 (MICU1) and Mitochondrial Ca2+ Uniporter (MCU) Contribute to Metabolism-Secretion Coupling in Clonal Pancreatic β-Cells

2. 7. Approaches to Glycemic Treatment

3. Removal of Ca2+ Channel β3 Subunit Enhances Ca2+ Oscillation Frequency and Insulin Exocytosis

4. Slow and fast oscillations of cytoplasmic Ca2+ in pancreatic islets correspond to pulsatile insulin release

5. Role of Oscillations in Membrane Potential, Cytoplasmic Ca2+, and Metabolism for Plasma Insulin Oscillations

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