Outcomes following intolerance to calcineurin inhibitor‐based graft‐versus‐host disease prophylaxis in children after allogeneic hematopoietic cell transplantation-Reference-Cited by-同舟云学术

Outcomes following intolerance to calcineurin inhibitor‐based graft‐versus‐host disease prophylaxis in children after allogeneic hematopoietic cell transplantation

Published:2023-06-20 Issue:9 Volume:70 Page:
ISSN:1545-5009
Container-title:Pediatric Blood & Cancer
language:en
Short-container-title:Pediatric Blood & Cancer

Author:

Wu Diana¹,Li Ying²,Bi Yu³^ORCID,Lannom Trevor M.¹,Ward Deborah A.¹,Qudeimat Amr²⁴,Madden Renee M.²,Sharma Akshay²^ORCID,Epperly Rebecca²⁴^ORCID,Mamcarz Ewelina²⁴,Talleur Aimee²⁴,Naik Swati²⁴,Selukar Subodh³^ORCID,Triplett Brandon²⁴^ORCID,Srinivasan Ashok²⁴^ORCID

Affiliation:

1. Department of Pharmacy and Pharmaceutical Sciences St. Jude Children's Research Hospital Memphis Tennessee USA

2. Department of Bone Marrow Transplantation and Cellular Therapy St. Jude Children's Research Hospital Memphis Tennessee USA

3. Department of Biostatistics St. Jude Children's Research Hospital Memphis Tennessee USA

4. Department of Pediatrics University of Tennessee Health Science Center Memphis Tennessee USA

Abstract

AbstractCalcineurin inhibitors (CNI), cyclosporine and tacrolimus, are commonly used for pharmacologic prophylaxis of graft‐versus‐host disease after allogeneic hematopoietic cell transplantation (HCT). Unfortunately, their use is associated with significant toxicities. While intolerance to CNI is well defined, there is very little information on how they impact outcomes after HCT in children. Our retrospective study in a cohort of 82 children shows a high intolerance rate of 39% in this population associated with lower event‐free survival and a higher transplant‐related mortality.

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/pbc.30517

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