Tamoxifen Inhibits TGF-β-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2-Reference-Cited by-同舟云学术

Tamoxifen Inhibits TGF-β-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2

Published:2015-08-24 Issue:12 Volume:230 Page:3084-3092
ISSN:0021-9541
Container-title:Journal of Cellular Physiology
language:en
Short-container-title:J. Cell. Physiol.

Author:

Carthy Jon M.¹,Sundqvist Anders¹,Heldin Angelos¹,van DAM Hans¹²,Kletsas Dimitris³,Heldin Carl-Henrik¹,Moustakas Aristidis¹⁴

Affiliation:

1. Ludwig Institute for Cancer Research; Science for Life Laboratory, Biomedical Center, Uppsala University; Uppsala Sweden

2. Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands; Leiden University Medical Center; Leiden The Netherlands

3. Laboratory of Cell Proliferation and Ageing; Institute of Biosciences and Applications, National Centre for Scientific Research “Demokritos“; Athens Greece

4. Department of Medical Biochemistry and Microbiology, Science for Life Laboratory; Biomedical Center, Uppsala University; Uppsala Sweden

Funder

Ludwig Institute for Cancer Research

Swedish Cancer Society

Swedish Research Council

EU FP6 Networks of Excellence: ENDOTRACK and ENFIN

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,Physiology

Reference39 articles.

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3. Antiestrogens induce growth inhibition by sequential activation of p38 mitogen-activated protein kinase and transforming growth factor-β pathways in human breast cancer cells;Buck;Mol Endocrinol,2004

4. TGF-β1 targets the GSK-3β/β-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts;Caraci;Pharmacol Res,2008

5. Estrogen receptors inhibit Smad3 transcriptional activity through Ap-1 transcription factors;Cherlet;Mol Cell Biochem,2007

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