Conversion of leucine to β-hydroxy-β-methylbutyrate by α-keto isocaproate dioxygenase is required for a potent stimulation of protein synthesis in L6 rat myotubes-Reference-Cited by-同舟云学术

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Conversion of leucine to β-hydroxy-β-methylbutyrate by α-keto isocaproate dioxygenase is required for a potent stimulation of protein synthesis in L6 rat myotubes

Published:2015-05-14 Issue:1 Volume:7 Page:68-78
ISSN:2190-5991
Container-title:Journal of Cachexia, Sarcopenia and Muscle
language:en
Short-container-title:Journal of Cachexia, Sarcopenia and Muscle

Author:

Girón María D.¹^ORCID,Vílchez José D.¹,Salto Rafael¹,Manzano Manuel²,Sevillano Natalia¹,Campos Nefertiti²,Argilés Josep M.³,Rueda Ricardo²,López-Pedrosa José M.²

Affiliation:

1. Department of Biochemistry and Molecular Biology II; School of Pharmacy, University of Granada; Granada Spain

2. Abbott Nutrition R&D; Granada Spain

3. Cancer Research Group, Department de Bioquimica I Biologia Molecular; Facultat de Biologia, Universitat de Barcelona; Barcelona Spain

Funder

Abbott Laboratories

Publisher

Wiley

Subject

Physiology (medical),Orthopedics and Sports Medicine

Reference50 articles.

1. Lost in translation: regulation of skeletal muscle protein synthesis;Weigl;Curr Opin Pharmacol.,2012

2. The mTOR pathway in the control of protein synthesis;Wang;Physiology.,2006

3. Phosphorylation and functional inactivation of TSC2 by ERK implications for tuberous sclerosis and cancer pathogenesis;Ma;Cell.,2005

4. mTOR couples cellular nutrient sensing to organismal metabolic homeostasis;Howell;Trends Endocrinol Metab.,2011

5. Differential dose response of mTOR signaling to oral administration of leucine in skeletal muscle and liver of rats;Yoshizawa;Biosci Biotechnol Biochem.,2013

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