Variability of Intestinal Expression of P-Glycoprotein in Healthy Volunteers as Described by Absorption of Talinolol from Four Bioequivalent Tablets

Author:

Siegmund Werner,Ludwig Karen,Engel Georg,Zschiesche Michael,Franke Gerd,Hoffmann Anna,Terhaag Bernd,Weitschies Werner

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference35 articles.

1. Talinolol, ein klinisch bewährter β1‐selektiver Betablocker—Eine Übersicht zu pharmakokinetischen und pharmakodynamischen Eigenschaften;Schmidt;Perfusion,1995

2. Induction of P‐glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: A new type of drug/drug interaction;Westphal;Clin Pharmacol Ther,2000

3. Direct demonstration of small intestinal secretion and site‐dependent absorption of the β‐blocker talinolol in humans;Gramatté;Clin Pharmacol Ther,1996

4. Is the double peak phenomenon of talinolol caused by lymphatic transport?;Giessmann;Pharmacol Toxicol,2001

5. Oral bioavailability of digoxin is enhanced by talinolol: Evidence for involvement of intestinal P‐glycoprotein;Westphal;Clin Pharmacol Ther,2000

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