Phase IIa trial of fingolimod for amyotrophic lateral sclerosis demonstrates acceptable acute safety and tolerability

Author:

Berry James D.12,Paganoni Sabrina12,Atassi Nazem12,Macklin Eric A.12,Goyal Namita3,Rivner Michael4,Simpson Ericka5,Appel Stanley5,Grasso Daniela L.1,Mejia Nicte I.1,Mateen Farrah1,Gill Alan6,Vieira Fernando6,Tassinari Valerie6,Perrin Steven6

Affiliation:

1. Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School; 165 Cambridge Street, Suite 600, Boston Massachusetts 02114 USA

2. Department of Neurology; Harvard Medical School; Boston Massachusetts USA

3. Department of Neurology; University of California; Irvine, Orange California USA

4. Department of Neurology; Augusta University Medical Center; Augusta Georgia USA

5. Department of Neurology; Methodist Hospital; Houston Texas USA

6. ALS Therapy Development Institute; Cambridge Massachusetts USA

Funder

ALS Therapy Development Institute

Novartis

Publisher

Wiley

Subject

Physiology (medical),Cellular and Molecular Neuroscience,Clinical Neurology,Physiology

Reference31 articles.

1. Amyotrophic lateral sclerosis;Wijesekera;Orphanet J Rare Dis,2009

2. Long-term survival in amyotrophic lateral sclerosis: a population-based study;Pupillo;Ann Neurol,2014

3. A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group;Bensimon;N Engl J Med,1994

4. Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND);Miller;Cochrane Database Syst Rev,2012

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