Impact of CYP2D6 Functional Allelic Variations on Phenoconversion and Drug-Drug Interactions

Author:

Storelli Flavia12,Matthey Alain1,Lenglet Sébastien3,Thomas Aurélien345,Desmeules Jules1246,Daali Youssef1246

Affiliation:

1. Division of Clinical Pharmacology and Toxicology; Geneva University Hospitals; Geneva Switzerland

2. Geneva-Lausanne School of Pharmacy; University of Geneva; Geneva Switzerland

3. Unit of Toxicology, CURML; Lausanne-Geneva Switzerland

4. Swiss Center for Applied Human Toxicology; Geneva Switzerland

5. Faculty of Biology and Medicine, Lausanne University Hospital, University of Lausanne; Lausanne Switzerland

6. Faculty of Medicine, University of Geneva; Geneva Switzerland

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference41 articles.

1. Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry;Zanger;Naunyn Schmiedebergs Arch. Pharmacol,2004

2. Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity;Ingelman-Sundberg;Pharmacogenomics J,2005

3. Prediction of CYP2D6 phenotype from genotype across world populations;Gaedigk;Genet. Med,2017

4. Human Cytochrome P450 (CYP) Allele Nomenclature Database http://www.cypalleles.ki.se

5. The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype;Gaedigk;Clin. Pharmacol. Ther,2008

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