Application of a systems pharmacology model for translational prediction of hERG ‐mediated QT c prolongation-Reference-Cited by-同舟云学术

Application of a systems pharmacology model for translational prediction of hERG ‐mediated QT c prolongation

Published:2016-11-17 Issue:6 Volume:4 Page:
ISSN:2052-1707
Container-title:Pharmacology Research & Perspectives
language:en
Short-container-title:Pharmacol Res Perspect

Author:

Gotta Verena¹²,Yu Zhiyi³,Cools Frank⁴,Ammel Karel⁴,Gallacher David J.⁴,Visser Sandra A. G.⁵,Sannajust Frederick⁶,Morissette Pierre⁶,Danhof Meindert¹,Graaf Piet H.¹⁷

Affiliation:

1. Systems Pharmacology Leiden Academic Centre for Drug Research (LACDR) Leiden University Leiden The Netherlands

2. Pediatric Pharmacology and Pharmacometrics University of Basel Children's Hospital (UKBB) Basel Switzerland

3. Division of Medicinal Chemistry Leiden Academic Centre for Drug Research (LACDR) Leiden University Leiden The Netherlands

4. Global Safety Pharmacology Janssen Research & Development Janssen Pharmaceutica NV Beerse Belgium

5. Quantitative Pharmacology and Pharmacometrics/Merck Research Laboratories Merck & Co., Inc. Upper Gwynedd Pennsylvania

6. SALAR‐Safety and Exploratory Pharmacology Department/Merck Research Laboratories Merck & Co., Inc. West Point Pennsylvania

7. Certara Quantitative Systems Pharmacology Canterbury United Kingdom

Funder

Dutch Top Institute Pharma (TIPharma)

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/prp2.270

Reference63 articles.

1. Effect of cimetidine and ranitidine on pharmacokinetics and pharmacodynamics of a single dose of dofetilide

2. Mechanism of hERG K+ channel blockade by the fluoroquinolone antibiotic moxifloxacin

3. The pharmacokinetics and pharmacodynamics of oral dofetilide after twice daily and three times daily dosing

4. Pharmacodynamic effect of continuous vs intermittent dosing of dofetilide on QT interval

5. Pharmacokinetic, pharmacodynamic, and safety evaluation of an accelerated dose titration regimen of sotalol in healthy middle-aged subjects

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