A detection model for cognitive dysfunction based on volatile organic compounds from a large Chinese community cohort

Author:

Jiao Bin12345,Zhang Sizhe1,Bei Yuzhang6,Bu Guiwen6,Yuan Li6,Zhu Yuan1,Yang Qijie1,Xu Tianyan1,Zhou Lu1,Liu Qianqian1,Ouyang Ziyu1,Yang Xuan1,Feng Yong7,Tang Beisha12345,Chen Haibin7,Shen Lu12345

Affiliation:

1. Department of Neurology Xiangya Hospital Central South University Changsha China

2. National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha China

3. Engineering Research Center of Hunan Province in Cognitive Impairment Disorders Central South University Changsha China

4. Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases Changsha China

5. Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South University Changsha China

6. Department of Neurology Liuyang Jili Hospital Changsha China

7. Breax Laboratory PCAB Research Center of Breath and Metabolism Beijing China

Abstract

AbstractIntroductionWe explored whether volatile organic compound (VOC) detection can serve as a screening tool to distinguish cognitive dysfunction (CD) from cognitively normal (CN) individuals.MethodsThe cognitive function of 1467 participants was assessed and their VOCs were detected. Six machine learning algorithms were conducted and the performance was determined. The plasma neurofilament light chain (NfL) was measured.ResultsDistinguished VOC patterns existed between CD and CN groups. The CD detection model showed good accuracy with an area under the receiver‐operating characteristic curve (AUC) of 0.876. In addition, we found that 10 VOC ions showed significant differences between CD and CN individuals (p < 0.05); three VOCs were significantly related to plasma NfL (p < 0.005). Moreover, a combination of VOCs with NfL showed the best discriminating power (AUC = 0.877).DiscussionDetection of VOCs from exhaled breath samples has the potential to provide a novel solution for the dilemma of CD screening.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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