Repeated subcutaneous administrations of krokodil causes skin necrosis and internal organs toxicity in Wistar rats: putative human implications

Author:

Alves Emanuele Amorim1234ORCID,Brandão Pedro1,Neves João Filipe5,Cravo Sara Manuela5,Soares José Xavier6,Grund Jean-Paul C.789,Duarte José Alberto10ORCID,Afonso Carlos M.M.511,Pereira Netto Annibal Duarte12,Carvalho Félix1ORCID,Dinis-Oliveira Ricardo Jorge123ORCID

Affiliation:

1. UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy; University of Porto; Porto Portugal

2. IINFACTS-Institute of Research and Advanced Training in Health Sciences and Technologies, Department of Sciences; University Institute of Health Sciences (IUCS), CESPU, CRL; Gandra Portugal

3. Department of Public Health and Forensic Sciences, and Medical Education, Faculty of Medicine; University of Porto; Porto Portugal

4. EPSJV-Joaquim Venâncio Polytechnic School of Health; Oswaldo Cruz Foundation; Rio de Janeiro Brazil

5. Department of Chemical Sciences, Laboratory of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy; University of Porto; Porto Portugal

6. LAQV, REQUIMTE, Department of Chemical Sciences, Laboratory of Applied Chemistry, Faculty of Pharmacy; University of Porto; Porto Portugal

7. CVO-Addiction Research Centre; Utrecht The Netherlands

8. Department of Addictology, First Faculty of Medicine; Charles University, General University Hospital; Prague Czech Republic

9. Freudenthal Institute for Science and Mathematics Education; Utrecht University; Utrecht The Netherlands

10. CIAFEL, Faculty of Sport; University of Porto; Porto Portugal

11. Interdisciplinary Center of Marine and Environmental Investigation (CIIMAR/CIMAR); Porto Portugal

12. Department of Analytical Chemistry, Chemistry Institute; Fluminense Federal University; Niterói Brazil

Publisher

Wiley

Subject

Pharmacology (medical),Psychiatry and Mental health,Clinical Neurology,Neurology

Reference62 articles.

1. Acetylcholinesterase. Two types of inhibition by an organophosphorus compound: one the formation of phosphorylated enzyme and the other analogous to inhibition by substrate;Aldridge;Biochemical Journal,1969

2. The harmful chemistry behind krokodil (desomorphine) synthesis and mechanisms of toxicity;Alves;Forensic Science International,2015a

3. The harmful chemistry behind “krokodil”: Street-like synthesis and product analysis;Alves;Forensic Science International,2015b

4. GC-MS method for the analysis of thirteen opioids, cocaine and cocaethylene in whole blood based on a modified quechers extraction;Alves;Current Pharmaceutical Analysis,2016

5. Hyperphosphatemia aggravates cardiac fibrosis and microvascular disease in experimental uremia;Amann;Kidney International,2003

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