Methotrexate catabolism to 7-hydroxymethotrexate in rheumatoid arthritis alters drug efficacy and retention and is reduced by folic acid supplementation-Reference-Cited by-同舟云学术

Methotrexate catabolism to 7-hydroxymethotrexate in rheumatoid arthritis alters drug efficacy and retention and is reduced by folic acid supplementation

Published:2009-08 Issue:8 Volume:60 Page:2257-2261
ISSN:0004-3591
Container-title:Arthritis & Rheumatism
language:en
Short-container-title:Arthritis Rheum

Author:

Baggott Joseph E.,Morgan Sarah L.

Publisher

Wiley

Subject

Pharmacology (medical),Immunology,Rheumatology,Immunology and Allergy

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/art.24685/fullpdf

Reference15 articles.

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2. Evidence for two phenotypes in the metabolism of methotrexate to 7-hydroxymethotrexate in patients with rheumatoid arthritis;Baggott;Arthritis Rheum,2005

3. Pharmacokinetics of methotrexate and 7-hydroxy-methotrexate in plasma and bone marrow of children receiving low-dose oral methotrexate;Sonneveld;Cancer Chemother Pharmacol,1986

4. Hydroxylation of 4-amino-antifolates by partially purified aldehyde oxidase from rabbit liver;Fabre;Biochem Pharmacol,1986

5. Formation of 7-hydroxymethotrexate polyglutamyl derivatives and their cytotoxicity in human chronic myelogenous leukemia cells, in vitro;Fabre;Cancer Res,1985

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1. AB0263 THE LEVEL OF 7-HYDROXY METHOTREXATE IN BLOOD CELLS IN PATIENTS WITH RHEUMATOID ARTHRITIS DIRECTLY CORRELATES WITH THE LEVEL OF POLYGLUTAMATES OF METHOTREXATE;Annals of the Rheumatic Diseases;2021-05-19

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