Evaluation of samidorphan, a μ-opioid antagonist, in a drug discrimination assay in rats

Author:

Sgro Mario P.1,Modlin Deah L.1,Deaver Daniel R.2,Kallman Mary J.1,Todtenkopf Mark S.2ORCID

Affiliation:

1. Department of Biology; Formerly of Covance Laboratories; Greenfield Indiana

2. Department of Medical Affairs; Alkermes, Inc.; Waltham Massachusetts

Funder

Alkermes, Inc.

Publisher

Wiley

Subject

Drug Discovery

Reference12 articles.

1. Effects of acute oral naltrexone on the subjective and physiological effects of oral D-amphetamine and smoked cocaine in cocaine abusers;Comer;Neuropsychopharmacology,2013

2. Effects of oral loperamide on efficacy of naltrexone, baclofen and AM-251 in blocking ethanol self-administration in rats;Dean;Pharmacology, Biochemistry, and Behavior,2012

3. Evaluation of opioid modulation in major depressive disorder;Ehrich;Neuropsychopharmacology,2015

4. Food and Drug Administration 2017 Guidance for industry: Assessment of abuse potential of drugs http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm198650.pdf

5. Discontinuation syndrome associated with paroxetine in depressed patients: A retrospective analysis of factors involved in the occurrence of the syndrome;Himei;CNS Drugs,2006

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