Successful anti-scavenger receptor class B type I (SR-BI) monoclonal antibody therapy in humanized mice after challenge with HCV variants within vitroresistance to SR-BI-targeting agents

Author:

Vercauteren Koen1,Van Den Eede Naomi1,Mesalam Ahmed Atef1,Belouzard Sandrine2,Catanese Maria Teresa34,Bankwitz Dorothea5,Wong-Staal Flossie6,Cortese Riccardo7,Dubuisson Jean2,Rice Charles M.3,Pietschmann Thomas5,Leroux-Roels Geert1,Nicosia Alfredo78,Meuleman Philip1

Affiliation:

1. Department of Clinical Chemistry, Microbiology and Immunology; CEVAC; Gent Belgium

2. Institut Pasteur de Lille, Center for Infection & Immunity of Lille; Université Lille Nord de France; Inserm U1019 CNRS UMR8204, Université Lille Nord de France

3. Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease; Rockefeller University; New York NY USA

4. Department of Infectious Diseases; King's College London School of Medicine; Guy's Hospital London UK

5. Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI); Hannover Germany

6. iTherX Pharma Inc.; San Diego CA USA

7. CEINGE; Naples Italy

8. Department of Molecular Medicine and Medical Biotechnology; University of Naples Frederico II; Naples Italy

Funder

National Institutes of Health

Fonds Wetenschappelijk Onderzoek

Federaal Wetenschapsbeleid

European Commission

Helmholtz Association

Deutsche Forschungsgemeinschaft

Ghent University

The Greenberg Medical Research Institute

The Rockefeller University

The Starr Foundation

Publisher

Wiley

Subject

Hepatology

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