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Mitochondrial content is central to nuclear gene expression: Profound implications for human health

  • Published:2016-01-03 Issue:2 Volume:38 Page:150-156
  • ISSN:0265-9247
  • Container-title:BioEssays
  • language:en
  • Short-container-title:BioEssays

Author:

Muir Rebecca1,Diot Alan1,Poulton Joanna1

Affiliation:

1. Nuffield Department of Obstetrics and Gynaecology; University of Oxford; John Radcliffe Hospital; Oxford UK

Funder

Medical Research Council

Wellcome Trust

NewLife Foundation

Angus Memorial Mitochondrial Fund

NHS Specialized Services Rare Mitochondrial Disorders Service

Publisher

Wiley

Subject

General Biochemistry, Genetics and Molecular Biology

Reference74 articles.

1. Global variability in gene expression and alternative splicing is modulated by mitochondrial content;Guantes;Genome Res,2015

2. Connecting variability in global transcription rate to mitochondrial variability;das Neves;PLoS Biol,2010

3. The energetics of genome complexity;Lane;Nature,2010

4. Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming;Picard;Proc Natl Acad Sci USA,2014

5. Tuning a ménage à trois: co-evolution and co-adaptation of nuclear and organellar genomes in plants;Greiner;BioEssays,2013
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