Outcomes after definitive treatment for cutaneous angiosarcomas of the face and scalp: Reevaluating the role of surgery and radiation therapy-Reference-Cited by-同舟云学术

Outcomes after definitive treatment for cutaneous angiosarcomas of the face and scalp: Reevaluating the role of surgery and radiation therapy

Published:2023-06-05 Issue:8 Volume:45 Page:1943-1951
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Yoder Alison K¹^ORCID,Farooqi Ahsan S¹,Wernz Cort²,Subramaniam Aparna³,Ravi Vinod³,Goepfert Ryan⁴^ORCID,Sturgis Erich M⁵,Mitra Devarati¹,Bishop Andrew J¹,Guadagnolo B Ashleigh¹

Affiliation:

1. Department of Radiation Oncology MD Anderson Cancer Center Houston Texas USA

2. Baylor College of Medicine Houston Texas USA

3. Department of Sarcoma Medical Oncology MD Anderson Cancer Center Houston Texas USA

4. Department of Head and Neck Surgery MD Anderson Cancer Center Houston Texas USA

5. Department of Otolaryngology—Head and Neck Surgery Baylor College of Medicine Houston Texas USA

Abstract

AbstractIntroductionWe investigated outcomes and prognostic factors for patients treated for cutaneous angiosarcoma (CA).MethodsWe conducted a retrospective review of patients treated for CA of the face and scalp from 1962 to 2019. All received definitive treatment with surgery, radiation (RT), or a combination (S‐XRT). The Kaplan–Meier method was used to estimate outcomes. Multivariable analyses were conducted using the Cox proportional hazards model.ResultsFor the 143 patients evaluated median follow‐up was 33 months. Five‐year LC was 51% and worse in patients with tumors >5 cm, multifocal tumors, those treated pre‐2000, and with single modality therapy (SMT). These remained associated with worse LC on multivariable analysis. The 5‐year disease‐specific survival (DSS) for the cohort was 56%. Tumor size >5 cm, non‐scalp primary site, treatment pre‐2000, and SMT were associated with worse DSS.ConclusionLarge or multifocal tumors are negative prognostic factors in patients with head and neck CA. S‐XRT improved outcomes.

Publisher

Wiley

Subject

Otorhinolaryngology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27418

Reference29 articles.

1. Histopathological diagnosis of cutaneous vascular sarcomas;Costache M;Rom J Morphol Embryol,2010

2. Cutaneous soft tissue sarcoma incidence patterns in the U.S.

3. Cutaneous angiosarcoma. Analysis of 434 cases from the Surveillance, Epidemiology, and End Results Program, 1973-2007

4. Angiosarcomas, a heterogeneous group of sarcomas with specific behavior depending on primary site: a retrospective study of 161 cases

5. Angiosarcoma of the face and scalp, prognosis and treatment