A novel glucagon-like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice

Author:

Valdecantos M. Pilar12,Pardo Virginia12,Ruiz Laura12,Castro-Sánchez Luis3,Lanzón Borja4,Fernández-Millán Elisa25,García-Monzón Carmelo67,Arroba Ana I.12,González-Rodríguez Águeda67,Escrivá Fernando25,Álvarez Carmen25,Rupérez Francisco J.4,Barbas Coral4,Konkar Anish8,Naylor Jacqui9,Hornigold David9,Santos Ana Dos9,Bednarek Maria9,Grimsby Joseph8,Rondinone Cristina M.8,Valverde Ángela M.12

Affiliation:

1. Instituto de Investigaciones Biomédicas Alberto Sols (Centro Mixto CSIC-UAM); Madrid Spain

2. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem); Instituto de Salud Carlos III; Madrid Spain

3. University of Colima; Colima Mexico

4. Centre for Metabolomics and Bioanalysis (CEMBIO); Faculty of Pharmacy, Universidad San Pablo CEU; Campus Monteprincipe Madrid Spain

5. Departamento de Bioquímica y Biología Molecular II; Facultad de Farmacia, Universidad Complutense; Madrid Spain

6. Liver Research Unit; Instituto de Investigación Sanitaria Princesa, University Hospital Santa Cristina; CIBERehd Madrid Spain

7. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III; Madrid Spain

8. MedImmune LLC; Gaithersburg MD

9. MedImmune Ltd; Cambridge UK

Funder

Ministerio de Economía y Competitividad

CIBERdem (ISCIII, Spain)

INFLAMES

European Foundation for the Study of Diabetes

Publisher

Wiley

Subject

Hepatology

Reference49 articles.

1. Management of NAFLD: a stage-based approach;Rinella;Nat Rev Gastroenterol Hepatol,2016

2. Liver transplantation and non-alcoholic fatty liver disease;Zezos;World J Gastroenterol,2014

3. Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis;Marra;Trends Mol Med,2008

4. Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas;Michalopoulos;Am J Pathol,2010

5. Surgical resection versus liver transplant for patients with hepatocellular carcinoma;Taefi;Cochrane Database Syst Rev,2013

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