Affiliation:
1. Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy and Joint Research Institution of Altitude Health and National Clinical Research Center for Geriatrics，West China Hospital Sichuan University Sichuan Chengdu China
2. Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health, Frontiers Science Center for Disease‐Related Molecular Network, West China Hospital Sichuan University Chengdu Sichuan China
Abstract
AbstractParkinson's disease (PD) is a multifactorial disease due to a complex interplay between genetic and epigenetic factors. Recent efforts shed new light on the epigenetic mechanisms involved in regulating pathways related to the development of PD, including DNA methylation, posttranslational modifications of histones, and the presence of microRNA (miRNA or miR). Epigenetic regulators are potential therapeutic targets for neurodegenerative disorders. In the review, we aim to summarize mechanisms of epigenetic regulation in PD, and describe how the DNA methyltransferases, histone deacetylases, and histone acetyltransferases that mediate the key processes of PD are attractive therapeutic targets. We discuss the use of inhibitors and/or activators of these regulators in PD models or patients, and how these small molecule epigenetic modulators elicit neuroprotective effects. Further more, given the importance of miRNAs in PD, their contributions to the underlying mechanisms of PD will be discussed as well, together with miRNA‐based therapies.
Funder
National Natural Science Foundation of China
China Postdoctoral Science Foundation
Subject
Drug Discovery,Pharmacology,Molecular Medicine
Cited by
10 articles.
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