Arctigenin, a Natural Lignan Compound, Induces Apoptotic Death of Hepatocellular Carcinoma Cells via Suppression of PI3-K/Akt Signaling

Author:

Jiang Xiaoxin12,Zeng Leping2,Huang Jufang2,Zhou Hui3,Liu Yubin4

Affiliation:

1. The First Affiliated Hospital; University of South China; Hengyang 421001 People's Republic of China

2. Department of Anatomy and Neurobiology, Biology Postdoctoral Workstation; Basic School of Medicine Central South University; Changsha 410013 People's Republic of China

3. Tumor Hospital Xiangya School of Medicine of Central South University; Changsha 410013 People's Republic of China

4. Department of General Surgery, Guangdong General Hospital; Guangdong Academy of Medical Sciences; Guangzhou 510080 People's Republic of China

Funder

Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Toxicology,Molecular Biology,Molecular Medicine,Biochemistry,General Medicine

Reference26 articles.

1. Hepatocellular carcinoma: western and eastern surgeons' points of view;Vibert;J. Visc. Surg.,2012

2. Multimodal treatment of hepatocellular carcinoma;Graf;Eur. J. Intern. Med.,2014

3. Improved chemotherapy for hepatocellular carcinoma;Cao;Anticancer Res.,2012

4. Exploiting the PI3K/AKT pathway for cancer drug discovery;Hennessy;Nat. Rev. Drug Discov.,2005

5. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex;Sarbassov;Science,2005

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