Allocentric information represented by self‐referenced spatial coding in the primate medial temporal lobe

Abstract

AbstractFor living organisms, the ability to acquire information regarding the external space around them is critical for future actions. While the information must be stored in an allocentric frame to facilitate its use in various spatial contexts, each case of use requires the information to be represented in a particular self‐referenced frame. Previous studies have explored neural substrates responsible for the linkage between self‐referenced and allocentric spatial representations based on findings in rodents. However, the behaviors of rodents are different from those of primates in several aspects; for example, rodents mainly explore their environments through locomotion, while primates use eye movements. In this review, we discuss the brain mechanisms responsible for the linkage in nonhuman primates. Based on recent physiological studies, we propose that two types of neural substrates link the first‐person perspective with allocentric coding. The first is the view‐center background signal, which represents an image of the background surrounding the current position of fixation on the retina. This perceptual signal is transmitted from the ventral visual pathway to the hippocampus (HPC) via the perirhinal cortex and parahippocampal cortex. Because images that share the same objective‐position in the environment tend to appear similar when seen from different self‐positions, the view‐center background signals are easily associated with one another in the formation of allocentric position coding and storage. The second type of neural substrate is the HPC neurons' dynamic activity that translates the stored location memory to the first‐person perspective depending on the current spatial context.