Affiliation:
1. Department of Anatomy and Cell Biology, Faculty of Medicine University of Yamanashi Chuo Yamanashi Japan
2. KMU Biobank Center, Institute of Biomedical Science Kansai Medical University Hirakata, Osaka Japan
Abstract
AbstractThe hippocampus is a center for spatial and episodic memory formation in rodents. Understanding the composition of subregions and circuitry maps of the hippocampus is essential for elucidating the mechanism of memory formation and recall. For decades, the trisynaptic circuit (entorhinal cortex layer II—dentate gyrus — CA3—CA1) has been considered the neural network substrate responsible for learning and memory. Recently, CA2 has emerged as an important area in the hippocampal circuitry, with distinct functions from those of CA3. In this article, we review the historical definition of the hippocampal area CA2 and the differential projection patterns between CA2 and CA3 pyramidal neurons. We provide a concise and comprehensive map of CA2 outputs by comparing (1) ipsi versus contra projections, (2) septal versus temporal projections, and (3) lamellar structures of CA2 and CA3 pyramidal neurons.
Funder
Japan Society for the Promotion of Science
Takeda Science Foundation
Cited by
2 articles.
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