Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5-alpha reductase type 1
Author:
Publisher
Wiley
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference53 articles.
1. Testosterone metabolism in male rat epiphysis
2. Androgen Metabolism by Human Fetal Epiphyseal Cartilage and Its Chondrocytes in Primary Culture*
3. Estrogen, Progesterone and Testosterone Receptors in Human Fetal Cartilaginous Tissue: Immunohistochemical Studies
4. Cell-type-specific expression of rat steroid 5 alpha-reductase isozymes.
5. Age-dependent responsiveness of rabbit and human cartilage cells to sex steroids in vitro
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1. Lower serum testosterone is associated with increased likelihood of arthritis;Scientific Reports;2023-11-07
2. Sex-dependent variation in cartilage adaptation: from degeneration to regeneration;Biology of Sex Differences;2023-04-05
3. Sex-specific effects of 17β-estradiol and dihydrotestosterone (DHT) on growth plate chondrocytes are dependent on both ERα and ERβ and require palmitoylation to translocate the receptors to the plasma membrane;Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids;2021-12
4. Lower androgen levels promote abnormal cartilage development in female patients with adolescent idiopathic scoliosis;Annals of Translational Medicine;2021-05
5. Consequences of steroid-5α-reductase deficiency and inhibition in vertebrates;General and Comparative Endocrinology;2020-05
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