Anticancer effect of superoxide dismutase on canine mammary gland tumour in vitro

Author:

Ko Byung‐Gee1,An Ju‐Hyun2ORCID,Lee Jeong‐Hwa1,Kim Kyeong‐Bo1,Kim Tae‐Hyeon1,Park Su‐Min1,Chae Hyung‐Kyu1,Youn Hwa‐Young1ORCID

Affiliation:

1. Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University Seoul Republic of Korea

2. Department of Veterinary Emergency and Critical Care Medicine and Institute of Veterinary Science College of Veterinary Medicine, Kangwon National University Chuncheon‐si Republic of Korea

Abstract

AbstractBackgroundReactive oxygen species (ROS) have been shown to promote tumour growth and metastasis in human cell lines. The superoxide anion (•O2) is produced during ROS formation and is involved in tumour cell signalling.ObjectivesSuperoxide dismutase (SOD) has been applied to canine mammary gland tumours to investigate its antitumour effects in vitro.MethodsCell proliferation, cell cycle cell migration assays, reverse transcription‐quantitative polymerase chain reaction, and western blot analysis were performed to determine the effects of SOD on canine mammary tumour cell line.ResultsSOD treatment resulted in anti‐proliferative effects and mediated cell cycle arrest in the canine mammary gland tumour cell lines (CIPp and CIPm). It also downregulated the expression of N‐cadherin and Vimentin.ConclusionsThe results confirmed that SOD inhibits tumour cell proliferation and migration, thus supporting the potential applications of SOD as a chemotherapeutic agent for canine mammary gland tumours.

Publisher

Wiley

Subject

General Veterinary

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