αE-catenin is a candidate tumor suppressor for the development of E-cadherin-expressing lobular-type breast cancer

Author:

de Groot Jolien S1,Ratze Max AK1,van Amersfoort Miranda1,Eisemann Tanja1,Vlug Eva J1,Niklaas Mijanou T1,Chin Suet-Feung2,Caldas Carlos2,van Diest Paul J1,Jonkers Jos3ORCID,de Rooij Johan4,Derksen Patrick WB1ORCID

Affiliation:

1. Department of Pathology; University Medical Center Utrecht; Utrecht The Netherlands

2. Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge Department of Oncology; University of Cambridge, Addenbrooke's Hospital, Cambridge Experimental Cancer Medicine Centre and NIHR Cambridge Biomedical Research Centre; Cambridge UK

3. Department of Molecular Pathology; Netherlands Cancer Institute; Amsterdam The Netherlands

4. Department of Molecular Cancer Research; University Medical Center Utrecht; Utrecht The Netherlands

Funder

H2020 European Institute of Innovation and Technology

KWF Kankerbestrijding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Foundation Vrienden UMC Utrecht

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Reference42 articles.

1. E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain;Berx;Oncogene,1996

2. Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis;Derksen;Cancer Cell,2006

3. Lobular breast cancer: pathology, biology, and options for clinical intervention;Vlug;Arch Immunol Ther Exp,2013

4. Loss of E-cadherin-dependent cell-cell adhesion and the development and progression of cancer;Bruner;Cold Spring Harb Perspect Biol,2018

5. PTEN loss in E-cadherin-deficient mouse mammary epithelial cells rescues apoptosis and results in development of classical invasive lobular carcinoma;Boelens;Cell Rep,2016

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