Identification of plasma protease derived metabolites of glucagon and their formation under typical laboratory sample handling conditions

Author:

Howard James W.12,Kay Richard G.1,Tan Tricia3,Minnion James3,Creaser Colin S.2

Affiliation:

1. LGC; Newmarket Road Fordham CB7 5WW UK

2. Centre for Analytical Science, Department of Chemistry; Loughborough University; Loughborough LE11 3TU UK

3. Imperial College; Department of Investigative Medicine, Hammersmith Hospital Campus; Du Cane Road London W12 0NN UK

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Analytical Chemistry

Reference37 articles.

1. Glucagon/insulin ratio as a potential biomarker for pancreatic cancer in patients with new-onset diabetes mellitus;Kolb;Cancer Biol. Ther.,2009

2. Glucagon metabolism in man, studies on the metabolic clearance rate and the plasma acute disappearance time of glucagon in normal and diabetic subjects;Alford;J. Clin. Endocrinol. Metab.,1976

3. Glucagon receptors;Authier;Cell. Mol. Life Sci.,2008

4. Characterization of a glucagon receptor-linked protease from canine hepatic plasma membranes. Partial purification, kinetic analysis, and determination of sites for hormone processing;Sheetz;J. Biol. Chem.,1988

5. Hepatic glucagon metabolism. Correlation of hormone processing by isolated canine hepatocytes with glucagon metabolism in man and in the dog;Hagopian;J. Clin. Invest.,1987

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