Affiliation:
1. Department of Neurology Kantonsspital St. Gallen Gallen Switzerland
2. Memory and Aging Center University of California San Francisco San Francisco California USA
3. Geriatrische Klinik St. Gallen Gallen Switzerland
4. Memory Clinic, University Department of Geriatric Medicine Felix Platter Basel Switzerland
Abstract
AbstractIntroduction: Cognition often remains unassessed in primary care. To improve early diagnosis of neurocognitive disorder (NCD) in Switzerland, the tablet‐based UCSF brain health assessment (BHA) and brain health survey (BHS) were validated.Methods: The German BHA, BHS, and Montreal Cognitive Assessment (MoCA) were administered to 67 patients with mild/major NCD and 50 controls. BHA includes subtests of memory, executive, visuospatial, and language functioning, and informant‐based BHS asks about behavior and motor functioning.Results: The complete instrument (BHA + BHS) was most accurate at detecting mild NCD (AUC = 0.95) and NCD without amyloid pathology (AUC = 0.96), followed by the BHA. All measures were accurate (all AUCs > 0.95) at distinguishing major NCD and NCD with amyloid pathology (Alzheimer's disease [AD]) from controls.Discussion: The German BHA and BHS are more sensitive to mild NCD and non‐AD presentations than the MoCA and thus have a high potential to identify patients with NCD in primary care earlier than currently used screens.
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