Self‐healing and cell adhesion properties of dynamic and photo‐crosslinking PEG‐based dual networks soft hydrogels

Abstract

AbstractSelf‐healing involves an autonomic response that repairs damage to living systems. In this study, polyethylene glycol (PEG) underwent aldehyde‐functionalization using the Albrigh Goldman oxidation technique. Flexible, dynamic crosslink points to encourage self‐healing are generated by the formation of acylhydrazone bonds formed between long‐chain PEG dialdehyde and adipic acid dihydrazide. Furthermore, methacrylated PEG was synthesized to support the polymer matrix through dynamic covalent bonds. The hydrogels exhibited self‐healing within the first 4 hours at room temperature and after 24 h. hydrogels with mechanical performance close to the original were obtained. They have good tensile and elongation strength and are well‐suited for interaction with living cells.