Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor-Reference-Cited by-同舟云学术

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Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor

Published:2022-09-27 Issue:11 Volume:237 Page:4303-4316
ISSN:0021-9541
Container-title:Journal of Cellular Physiology
language:en
Short-container-title:Journal Cellular Physiology

Author:

Phadwal Kanchan¹^ORCID,Koo Eve¹,Jones Ross A.²³,Forsythe Rachael O.⁴⁵,Tang Keyi¹,Tang Qiyu¹,Corcoran Brendan M.¹,Caporali Andrea⁴,MacRae Vicky E.¹

Affiliation:

1. The Roslin Institute and R(D)SVS The University of Edinburgh Edinburgh UK

2. Edinburgh Medical School The University of Edinburgh Edinburgh UK

3. Euan MacDonald Centre for Motor Neurone Disease Research The University of Edinburgh Edinburgh UK

4. Centre for Cardiovascular Science, The Queens Medical Research Institute University of Edinburgh Edinburgh UK

5. Department of Vascular Surgery Edinburgh Royal Infirmary Edinburgh UK

Funder

Biotechnology and Biological Sciences Research Council

British Heart Foundation

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,Physiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcp.30887

Reference58 articles.

1. Human ATG4 autophagy proteases counteract attachment of ubiquitin-like LC3/GABARAP proteins to other cellular proteins

2. Ablation of Adenosine Monophosphate-Activated Protein Kinase α1 in Vascular Smooth Muscle Cells Promotes Diet-Induced Atherosclerotic Calcification In Vivo

3. Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis

4. Metformin Inhibits Vascular Calcification in Female Rat Aortic Smooth Muscle Cells via the AMPK-eNOS-NO Pathway

5. Metformin attenuates angiotensin II-induced TGFβ1 expression by targeting hepatocyte nuclear factor-4-α

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