Drug-induced Proarrhythmia and Torsade de Pointes: A Primer for Students and Practitioners of Medicine and Pharmacy

Author:

Turner J. Rick1,Rodriguez Ignacio2,Mantovani Emily3,Gintant Gary4,Kowey Peter R.5,Klotzbaugh Ralph J.6,Prasad Krishna7,Sager Philip T.8,Stockbridge Norman9,Strnadova Colette10,

Affiliation:

1. Campbell University College of Pharmacy & Health Sciences; Buies Creek NC USA

2. Cardiac Safety Research Consortium; Roche TCRC, Inc.; New York NY USA

3. Ernest Mario School of Pharmacy; Rutgers University; Piscataway NJ USA

4. AbbVie; Chicago IL USA

5. Lankenau Heart Institute and Jefferson Medical College; Philadelphia PA USA

6. College of Nursing and Health Sciences; University of Massachusetts Boston; Boston MA USA

7. Medicines and Healthcare Products Regulatory Agency; London UK

8. Sager Consulting and Stanford University; San Francisco CA USA

9. Center for Drug Evaluation and Research; US Food and Drug Administration; Silver Spring MD USA

10. Therapeutic Products Directorate; Health Canada; Ottawa Ontario Canada

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference124 articles.

1. Evaluation of toxicity for heart failure therapeutics: studying effects on the QT interval;Link;Circ Heart Fail,2010

2. ICH ICHHarmonised Tripartite Guideline 2005 http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Safety/S7B/Step4/S7B_Guideline.pdf

3. ICH ICH Guideline Harmonised Tripartite Guideline 2005 http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Efficacy/E14/E14_Guideline.pdf

4. ICH E14 Implementation Working Group 2015 http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Efficacy/E14/E14_Q_As_R3__Step4.pdf

5. La tachycardie ventriculaire a deux foyers opposes variables;Dessertenne;Arch Mal Coeur Vaiss,1966

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