A comprehensive gene–environment interaction analysis in Ovarian Cancer using genome‐wide significant common variants

Author:

Kim Sehee1,Wang Miao1,Tyrer Jonathan P.2,Jensen Allan3,Wiensch Ashley4,Liu Gang5,Lee Alice W.6,Ness Roberta B.7,Salvatore Maxwell14ORCID,Tworoger Shelley S.89,Whittemore Alice S.1011,Anton‐Culver Hoda12ORCID,Sieh Weiva13,Olson Sara H.14,Berchuck Andrew15,Goode Ellen L.16ORCID,Goodman Marc T.1718,Doherty Jennifer Anne19,Chenevix‐Trench Georgia20,Rossing Mary Anne2122,Webb Penelope M.23,Giles Graham G.242526,Terry Kathryn L.927,Ziogas Argyrios12,Fortner Renée T.28ORCID,Menon Usha29,Gayther Simon A.303132,Wu Anna H.30ORCID,Song Honglin2,Brooks‐Wilson Angela3334,Bandera Elisa V.35,Cook Linda S.3637,Cramer Daniel W.927ORCID,Milne Roger L.242538,Winham Stacey J.16,Kjaer Susanne K.339,Modugno Francesmary404142ORCID,Thompson Pamela J.17,Chang‐Claude Jenny2843,Harris Holly R.21,Schildkraut Joellen M.44,Le Nhu D.45,Wentzensen Nico46,Trabert Britton46ORCID,Høgdall Estrid347,Huntsman David4849,Pike Malcolm C.1450ORCID,Pharoah Paul D.P.251,Pearce Celeste Leigh431ORCID,Mukherjee Bhramar1

Affiliation:

1. Department of Biostatistics University of Michigan School of Public Health Ann Arbor MI USA

2. Centre for Cancer Genetic Epidemiology, Department of Oncology University of Cambridge Cambridge United Kingdom

3. Department of Virus, Lifestyle and Genes Danish Cancer Society Research Center Copenhagen Denmark

4. Department of Epidemiology University of Michigan School of Public Health Ann Arbor MI USA

5. Department of Biostatistics Harvard T.H. Chan School of Public Health Boston MA USA

6. Department of Public Health California State University, Fullerton Fullerton CA USA

7. University of Texas School of Public Health Houston TX USA

8. Department of Cancer Epidemiology Moffitt Cancer Center Tampa FL USA

9. Department of Epidemiology, Harvard T.H. Chan School of Public Health Boston MA USA

10. Department of Health Research and Policy ‐ Epidemiology Stanford University School of Medicine Stanford CA USA

11. Department of Biomedical Data Science Stanford University School of Medicine Stanford CA USA

12. Department of Epidemiology Genetic Epidemiology Research Institute, University of California Irvine Irvine CA USA

13. Department of Genetics and Genomic Sciences, Department of Population Health Science and Policy Icahn School of Medicine at Mount Sinai New York NY USA

14. Department of Epidemiology and Biostatistics Memorial Sloan‐Kettering Cancer Center New York NY USA

15. Department of Obstetrics and Gynecology Duke University Medical Center Durham NC USA

16. Department of Health Sciences Research Mayo Clinic Rochester MN USA

17. Cancer Prevention and Control Samuel Oschin Comprehensive Cancer Institute, Cedars‐Sinai Medical Center Los Angeles CA USA

18. Department of Biomedical Sciences, Cedars‐Sinai Medical Center Community and Population Health Research Institute Los Angeles CA USA

19. Department of Population Health Sciences Huntsman Cancer Institute, University of Utah Salt Lake City UT USA

20. Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute Brisbane QLD Australia

21. Program in Epidemiology, Division of Public Health Sciences Fred Hutchinson Cancer Research Center Seattle WA USA

22. Department of Epidemiology University of Washington Seattle WA USA

23. Population Health Department QIMR Berghofer Medical Research Institute Brisbane QLD Australia

24. Cancer Epidemiology & Intelligence Division Cancer Council Victoria Melbourne VIC Australia

25. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health The University of Melbourne Melbourne Victoria Australia

26. Department of Epidemiology and Preventive Medicine Monash University Melbourne VIC Australia

27. Obstetrics and Gynecology Epidemiology Center Brigham and Women's Hospital Boston MA USA

28. Division of Cancer Epidemiology German Cancer Research Center (DKFZ) Heidelberg Germany

29. Gynaecological Cancer Research Centre, Women's Cancer Institute for Women's Health, University College London London United Kingdom

30. Department of Preventive Medicine, Keck School of Medicine University of Southern California Los Angeles CA USA

31. Center for Cancer Prevention and Translational Genomics Samuel Oschin Comprehensive Cancer Institute, Cedars‐Sinai Medical Center Los Angeles CA USA

32. Department of Biomedical Sciences Cedars‐Sinai Medical Center Los Angeles CA USA

33. Genome Sciences Centre BC Cancer Agency Vancouver BC Canada

34. Department of Biomedical Physiology and Kinesiology Simon Fraser University Burnaby BC Canada

35. Cancer Prevention and Control Program Rutgers Cancer Institute of New Jersey New Brunswick NJ USA

36. University of New Mexico Health Sciences Center University of New Mexico Albuquerque NM USA

37. Division of Cancer Care, Department of Population Health Research Alberta Health Services Calgary AB Canada

38. Precision Medicine, School of Clinical Sciences at Monash Health Monash University Clayton VIC Australia

39. Department of Gynaecology, Rigshospitalet University of Copenhagen Copenhagen Denmark

40. Ovarian Cancer Center of Excellence, Womens Cancer Research Program Magee‐Womens Research Institute and Hillman Cancer Center Pittsburgh PA USA

41. Department of Epidemiology University of Pittsburgh Graduate School of Public Health Pittsburgh PA USA

42. Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences University of Pittsburgh School of Medicine Pittsburgh PA USA

43. Cancer Epidemiology Group University Cancer Center Hamburg (UCCH), University Medical Center Hamburg‐Eppendorf Hamburg Germany

44. Department of Public Health Sciences University of Virginia Charlottesville VA USA

45. Cancer Control Research BC Cancer Agency Vancouver BC Canada

46. Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health Bethesda MD USA

47. Molecular Unit, Department of Pathology Herlev Hospital, University of Copenhagen Copenhagen Denmark

48. British Columbia's Ovarian Cancer Research (OVCARE) program Vancouver General Hospital, BC Cancer and University of British Columbia

49. Department of Pathology and Laboratory Medicine, and Obstetrics and Gynecology University of British Columbia Vancouver BC Canada

50. Department of Preventive Medicine, Keck School of Medicine University of Southern California Norris Comprehensive Cancer Center Los Angeles CA USA

51. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care University of Cambridge Cambridge United Kingdom

Funder

Canadian Institutes of Health Research

Rutgers Cancer Institute of New Jersey

Ovarian Cancer Research Fund

Deutsches Krebsforschungszentrum

Kræftens Bekæmpelse

Mayo Foundation for Medical Education and Research

Medical Research and Materiel Command

Minnesota Ovarian Cancer Alliance

National Cancer Institute

National Center for Research Resources

National Health and Medical Research Council

National Institute of Environmental Health Sciences

National Institutes of Health

National Science Foundation

Ovarian Cancer Australia

Seventh Framework Programme

U.S. Department of Defense

State of Connecticut Department of Public Health

Publisher

Wiley

Subject

Cancer Research,Oncology

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