Conjugating influenza a (H1N1) antigen to n-trimethylaminoethylmethacrylate chitosan nanoparticles improves the immunogenicity of the antigen after nasal administration

Author:

Liu Qingfeng1,Zheng Xiaoyao1,Zhang Chi1,Shao Xiayan1,Zhang Xi1,Zhang Qizhi1,Jiang Xinguo1

Affiliation:

1. Key Laboratory of Smart Drug Delivery (Fudan University); Ministry of Education; P. R. China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Infectious Diseases,Virology

Reference29 articles.

1. N-trimethyl chitosan (TMC) nanopartiscles loaded with influenza subunit antigen for intranasal vaccination: Biological properties and immunogenicity in a mouse model;Amidi;Vaccine,2007

2. Localized mucosal response to intranasal live attenuated influenza vaccine in adults;Barría;J Infect Dis,2013

3. Nanoparticles for nasal vaccination;Csaba;Adv Drug Deliv Rev,2009

4. Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells;Curtsinger;J Immunol,1999

5. Receptor-mediated stimulatory effect of oligochitosan in macrophages;Feng;Biochem Biophys Res Commun,2004

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