PBPK Modeling Strategy for Predicting Complex Drug Interactions of Letermovir as a Perpetrator in Support of Product Labeling-Reference-Cited by-同舟云学术

PBPK Modeling Strategy for Predicting Complex Drug Interactions of Letermovir as a Perpetrator in Support of Product Labeling

Published:2018-09-11 Issue:2 Volume:105 Page:515-523
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Wang Ying‐Hong¹,Chen Dapeng¹,Hartmann Georgy¹,Cho Carolyn R.¹,Menzel Karsten¹

Affiliation:

1. Merck Research Laboratories, Merck & Co.West Point Pennsylvania USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.1120

Reference37 articles.

1. The Novel Anticytomegalovirus Compound AIC246 (Letermovir) Inhibits Human Cytomegalovirus Replication through a Specific Antiviral Mechanism That Involves the Viral Terminase

2. Letermovir: First Global Approval

3. FDA.Letermovir Clinical Pharmacology and Biopharmaceutics Review. (2017). Assessed 12 January 2018.

4. McCrea A.A.et al.Letermovir moderately increases atorvastatin plasma exposure with coadministration. AAPS Annual Meeting and Exposition November 12–15 2017; San Diego CA;2017:M8081.

5. Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone

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