pH variations during diafiltration due to buffer nonidealities

Author:

Baek Youngbin1,Yang Deyu1,Singh Nripen2,Arunkumar Abhiram2,Ghose Sanchayita2,Li Zheng Jian2,Zydney Andrew L.1ORCID

Affiliation:

1. Dept. of Chemical Engineering; The Pennsylvania State University, University Park; PA 16802

2. Product Development; Bristol-Myers Squibb; Devens MA 01434

Publisher

Wiley

Subject

Biotechnology

Reference12 articles.

1. Bioprocess membrane technology;Reis;J Memb Sci.,2007

2. Protein−solute interactions affect the outcome of ultrafiltration/diafiltration operations;Stoner;J Pharm Sci.,2004

3. Effect of protein and solution properties on the Donnan effect during the ultrafiltration of proteins;Bolton;Biotechnol Progr.,2011

4. Accounting for the Donnan effect in diafiltration optimization for high-concentration UFDF applications;Steele;Bioprocess Intl.,2014

5. Theoretical analysis of excipient concentrations during the final ultrafiltration/diafiltration step of therapeutic antibody;Miao;Biotechnol Progr.,2009

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