Lithocholic Acid Stimulates IL-8 Expression in Human Colorectal Cancer Cells Via Activation of Erk1/2 MAPK and Suppression of STAT3 Activity

Author:

Nguyen Thi Thinh1,Lian Sen2,Ung Trong Thuan1,Xia Yong1,Han Jae Young1,Jung Young Do1ORCID

Affiliation:

1. Research Institute of Medical Sciences; Chonnam National University Medical School; Gwangju 501-190 Republic of Korea

2. Department of Biochemistry and Molecular Biology; School of Basic Medical Sciences; Guangdong Province Key Laboratory of Bioship Technology; Southern Medical University; Guangzhou 510515 Guangdong People's Republic of China

Funder

National Research Foundation of Korea

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference51 articles.

1. Prostaglandin E2 enhances interleukin 8 (IL-8) and IL-6 but inhibits GMCSF production by IL-1 stimulated human synovial fibroblasts in vitro;Agro;J Rheumatol,1996

2. Secondary bile acids: An underrecognized cause of colon cancer;Ajouz;World J Surg Oncol,2014

3. Lithocholic acid inhibits the expression of HLA class I genes in colon adenocarcinoma cells. Differential effect on HLA-A, -B and -C loci;Arvind;Mol Immunol,1994

4. Lithocholic acid upregulates uPAR and cell invasiveness via MAPK and AP-1 signaling in colon cancer cells;Baek;Cancer Lett,2010

5. STAT signaling in the pathogenesis and treatment of myeloid malignancies;Bar-Natan;JAKSTAT,2012

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