Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: A critical role for IL-6/STAT3

Author:

Xu Ming-Jiang12,Feng Dechun1,Wu Hailong3,Wang Hua1,Chan Yvonne4,Kolls Jay5,Borregaard Niels6,Porse Bo789,Berger Thorsten10,Mak Tak W.10,Cowland Jack B.6,Kong Xiaoni1311,Gao Bin1

Affiliation:

1. Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism; National Institutes of Health; Bethesda MD USA

2. Department of Physiology and Pathophysiology, School of Basic Medical Science, Peking University Health Science Center; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education; Beijing China

3. State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine; Shanghai Jiao Tong University; Shanghai China

4. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine; University of Pittsburgh; Pittsburgh PA USA

5. Richard King Mellon Foundation Institute for Pediatric Research; Children's Hospital of Pittsburgh; Pittsburgh PA USA

6. Granulocyte Research Laboratory; Rigshospitalet Copenhagen Denmark

7. Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences; University of Copenhagen; Denmark

8. Biotech Research and Innovation Center (BRIC); University of Copenhagen; Denmark

9. Danish Stem Cell Centre (DanStem) Faculty of Health Sciences; University of Copenhagen; Denmark

10. Campbell Family Institute for Breast Cancer Research; University Health Network; Toronto Ontario Canada

11. School of Biomedical Engineering & Med-X Research Institute; Shanghai Jiao Tong University; Shanghai China

Funder

National Institutes of Health

Publisher

Wiley

Subject

Hepatology

Reference35 articles.

1. Liver: an organ with predominant innate immunity;Gao;Hepatology,2008

2. Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans;Cowland;Genomics,1997

3. Lipocalin 2 is protective against E. coli pneumonia;Wu;Respir Res,2010

4. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase;Kjeldsen;J Biol Chem,1993

5. The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer;Chakraborty;Biochim Biophys Acta,2012

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